International Stem Cell Corporation, Through Its Subsidiary Lifeline Cell Technology, Announces the Launch and Sale of New Products into the Human...

International Stem Cell Corporation, Through Its Subsidiary Lifeline Cell Technology, Announces the Launch and Sale of New Products into the Human Cell Research Market

OCEANSIDE, Calif.--(BUSINESS WIRE)--International Stem Cell Corporation (OTCBB:ISCO) (www.internationalstemcell.com), announces that it has launched fifteen new human cell culture products into the commercial research markets over the last twelve months through its wholly-owned subsidiary, Lifeline Cell Technology, (Walkersville, MD), leading to a 12-month average month-to-month revenue growth of 50%. ISCO, the parent company, is the first company to create human “parthenogenetic” stem cells from unfertilized eggs. Parthenogenetic stem cells not only solve ethical problems, but also promise to minimize immune-rejection by providing cells that can be immune-matched to large segments of the population.

These products represent milestone achievements in ISCO’s strategy of generating revenue from the sale of research products, while building infrastructure from that effort to expand the manufacturing and quality control capacities ISCO needs to commercialize the therapeutic applications of human parthenogenetic stem cells.

One of its newest and most promising products consist of “xeno-free” human cells and culture reagents that allow researchers to study embryonic stem cells without contamination from animal (non-human) components. These products meet the needs for stem cell research to be done using “human-only” systems. Other products include Lifeline’s living human cells and reagents for research and drug development into cardiovascular, kidney, lung, nerve, eye and skin disease. Lifeline is continuing to develop unique reagents and media for the growing field of stem cell research. The “Lifeline” brand of products consist of human cells and the culture reagents and growth factors needed to grow the cells.

According to Jeffrey Janus, CEO of Lifeline, “We are proud of the quality of our new products, as reflected in the sales growth they are exhibiting in the human cell research markets. We look forward to launching more new products into the growing markets for stem cell research and drug development. These products will contribute to the success of ISCO, not only by supporting ISCO’s therapeutic research, but also through the development of critical manufacturing and quality control systems necessary for ISCO to produce therapeutic human cells in the future.”

Lifeline’s products can be found at www.lifelinecelltech.com

For more news and information on International Stem Cell Corporation please visit www.IRGnews.com/coi/ISCO where you can find the CEO’s video, a fact sheet on the company, investor presentations, and more.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California biotechnology company focused on developing therapeutic and research products. ISCO’s technology, Parthenogenesis, results in the creation of pluripotent human stem cell lines from unfertilized human eggs. ISCO scientists have created the first Parthenogenetic homozygous stem cell line (phSC-Hhom-4) that can be a source of therapeutic cells that will minimize immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. These advancements offer the potential to create the first true “Stem Cell Bank” and address ethical issues by eliminating the need to use or destroy fertilized embryos. ISCO also produces and markets specialized cells and growth media worldwide for therapeutic research through its subsidiary Lifeline Cell Technology. For more information, visit the ISCO website at: www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS:

Statements pertaining to anticipated future financial and/or operating results, future growth in research, technology, clinical development and potential joint venture and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Cornea, Parthenogenesis

ISCO Eyes See Path to Huge Profits by Patrick Cox

The attached article appeared recently in an independent journal, Agora Financial (agorafinancial.com) and we thought you would be interested. The author, Patrick Cox, is a very astute follower of the regenerative medicine field.



Dear Breakthrough Technology Reader,

The important Nobel Prize news last week was the recognition of three American scientists for their role in the discovery of telomerase. More attention was garnered by the rather puzzling Peace Prize award, but that has become routine. The five Norwegians who pick the Peace Prize winners are specifically selected, it seems, by Norway's liberal parliament primarily to comment on and meddle in American politics.

Regardless, the prize for medicine this year is extremely significant. Telomerase, as you know, is the “immortalizing enzyme,” produced by stem cells. When administered to adult cells, telomerase adds life-extending telomeres to the ends of a cell's DNA. There has been no more important discovery in the history of medicine.

The list of scientists credited with the discovery is sorely short, having ignored the contributions of Dr. Michael West, the CEO of BioTime (BTIM: OTCBB), and other critical researchers who have made crucial contributions to the current state of the science. I'm glad, however, that the award will help bring attention to regenerative medicine.

As more people learn what regenerative medicine can do, it will attract additional capital and accelerate progress. It will also, of course, push up the value of companies that hold important patents covering telomerase and other stem cell technologies.

The most important patents associated with telomerase and stem cells are already in our portfolio. Geron (GERN: NASDAQ) is the most obvious, with specific patent rights to telomerase. It's not the only company with critical IP in this area, however. This week, I'd like to update you on recent developments with another of our extremely important stem cell companies: International Stem Cell Corporation (ISCO: OTCBB). Once again, this is a longer alert than the usual weekly update, but ISCO is one of our most important stocks and it warrants a little extra attention.

ISCO's Parthenogenic Patent Strength

International Stem Cell, as I've explained before, holds all the major patents regarding parthenogenic stem cells (hpSCs). This alone makes the company worthy of investors' attention. Virtually every other stem cell company will share some future revenues, at least, with the Wisconsin Alumni Research Foundation, holder of certain basic SC patents. Moreover, ISCO already has an established laboratory supply business, Lifeline Cell Technology, that is on track to cover the expenses for the entire company. This is NOT a struggling company.

The big deal about ISCO, however, is its parthenogenic stem cell technology. These cells are derived from unfertilized ovum. They have only half the normal DNA and are, therefore, much, much easier to HLA match to minimize or eliminate immune reactions. They also have a huge near-term marketing advantage in that these cells have nothing to do with embryos and are, therefore, more acceptable to consumers who have ethical objections to the use of cells that could theoretically become embryos.

Of course, with the rise of iPS technologies, virtually any cell in your body could be transformed into an embryo. That, however, is a story I don't have the time or space to deal with today, though it is a fascinating story.

HLA, incidentally, is the acronym for human leukocyte antigens. These antigens determine how your body will respond to transplanted tissue. A close HLA match with a donor assures that transplants are well tolerated. A poor match can result in rejection or require significant immune system suppression, which has all kinds of undesirable side effects.

I think that induced pluripotent stem (iPS) cells are destined to be the “Cadillac” of stem cell treatments. A little of your blood can be used to produce stem cells that exactly match your body, provoking no immune reaction. For some time, however, iPS cells will be high-end therapies and relatively expensive.

The advantage that hpSCs have is that they hold the promise of cheap “off-the-shelf” therapies for a wide range of critical medical conditions. ISCO is working on hpSCs for renal failure, macular degeneration and severe diabetes. The company expects to enter clinical testing for macular degeneration soon. In the long term, they it also plans to produce cells for more dramatic therapies such as heart and vascular tree rejuvenation.

The genius of hpSC technology is that scientists believe it is possible to HLA match 99% of the world's population with a limited number of cell donors. Between 50-100 donors could provide the raw materials that would allow the mass production of incredibly powerful stem cell therapies that require little or no immune suppression. Even when iPS cell technology is developed and automated, in fact, I believe the market for these mass-market SC therapies will remain huge for decades.

Clearly, we're not quite there yet. ISCO needs more time, money and FDA approval. In the short run, however, the company has developed several important strategies for continuing growth.

One, as I mentioned above, is Lifeline. Another product, which has produced huge enthusiasm, is a skin stem cell growth media that ISCO scientists accidentally discovered to be an incredibly effective “cosmeceutical.” To the disappointment of many, ISCO has slowed the development process of this product to assure its safety and efficacy, but CEO Ken Aldrich tells me he expects to see it sold to clinics, at least, by Q1 next year.

Now, ISCO has announced another potential near- to midterm revenue blockbuster. As I've told you before, ISCO can already grow perfectly formed human corneas in petri dishes. Eventually, these corneas should provide hundreds of millions in revenues from the international market, where there are desperate shortages of transplant corneas.

ISCO is on track to filling another huge eye-related market. I'm talking about live animal drug and cosmetics testing.

As you probably know, many drugs and cosmetics are safety tested on the eyes of live animals. This is not only an incredibly expensive process, requiring facilities for breeding and taking care of animals, but it is extremely unpopular with consumers. While necessary, no one likes to think about the bunnies in bondage having potentially dangerous, damaging and painful chemicals put in their eyes. Neither, in fact, do the technicians who actually perform the tests.

ISCO's alternative is to provide actual human eye cells. These artificial eyes would not only have more accurate responses to substances than rabbits and other non-human subjects, they are far less expensive and experience no pain. The company is collaborating with a major provider of biological assay system, Absorption Systems, to get its artificial hpSC corneas pre-approved by the FDA and ready for market.

According to the press release, “The collaboration between the companies is focused on using Absorption Systems’ know-how in creating assay systems to develop superior preclinical methods of testing drugs. Such methods can also reduce the use of laboratory animals currently necessary for other tests, including the very large global commercial need for a reliable and reproducible non-animal method for eye safety testing of consumer products.

“In the past, researchers have grown corneal cells in the laboratory, but ISCO is believed to be the only company to grow a self-assembling corneal construct from parthenogenetic stem cells that is suitable for toxicity testing and possibly suitable for corneal transplants. ISCO’s corneal constructs include cell layers and structures normally found in a human cornea, as confirmed by an independent third-party laboratory.”

Let me be clear. This testing market is worth hundreds of millions of dollars. ISCO is not predicting how long it will take to get its alternative to live animal testing validated by the FDA, but I can't believe the administration will resist this product. I really don't think it will take “years,” simply because of the politics involved. Even the providers of live animals want an alternative to the current technology, because of consumer disapproval of their current testing methods.

If the FDA dared drag its feet on this issue, a phone call to PETA could turn this story into a high-profile political issue that no administration would want to deal with. I consider ISCO's decision to pursue this short-term product more evidence that this brilliantly run company will thrive until it can offer the really revolutionary products, including off-the-shelf SC injections that cure pancreatic, liver and heart disease.

Best of all, ISCO's stock prices have dipped recently, and for no detectable reason. This is a perfect opportunity for people who failed to buy when I first recommended the stock.

For transformational profits,

Patrick Cox
To read the article on the Agora Financial Website, please visit here

International Stem Cell Corporation, Through Its Subsidiary Lifeline Cell Technology, Announces the Launch and Sale of New Products into the Human...

International Stem Cell Corporation, Through Its Subsidiary Lifeline Cell Technology, Announces the Launch and Sale of New Products into the Human Cell Research Market

International Stem Cell Corporation (OTCBB:ISCO) (www.internationalstemcell.com), announces that it has launched fifteen new human cell culture products into the commercial research markets over the last twelve months through its wholly-owned subsidiary, Lifeline Cell Technology, (Walkersville, MD), leading to a 12-month average month-to-month revenue growth of 50%. ISCO, the parent company, is the first company to create human "parthenogenetic" stem cells from unfertilized eggs. Parthenogenetic stem cells not only solve ethical problems, but also promise to minimize immune-rejection by providing cells that can be immune-matched to large segments of the population.

These products represent milestone achievements in ISCO's strategy of generating revenue from the sale of research products, while building infrastructure from that effort to expand the manufacturing and quality control capacities ISCO needs to commercialize the therapeutic applications of human parthenogenetic stem cells.

One of its newest and most promising products consist of "xeno-free" human cells and culture reagents that allow researchers to study embryonic stem cells without contamination from animal (non-human) components. These products meet the needs for stem cell research to be done using "human-only" systems. Other products include Lifeline's living human cells and reagents for research and drug development into cardiovascular, kidney, lung, nerve, eye and skin disease. Lifeline is continuing to develop unique reagents and media for the growing field of stem cell research. The "Lifeline" brand of products consist of human cells and the culture reagents and growth factors needed to grow the cells.

According to Jeffrey Janus, CEO of Lifeline, "We are proud of the quality of our new products, as reflected in the sales growth they are exhibiting in the human cell research markets. We look forward to launching more new products into the growing markets for stem cell research and drug development. These products will contribute to the success of ISCO, not only by supporting ISCO's therapeutic research, but also through the development of critical manufacturing and quality control systems necessary for ISCO to produce therapeutic human cells in the future."

Lifeline's products can be found at www.lifelinecelltech.com

For more news and information on International Stem Cell Corporation please visit www.IRGnews.com/coi/ISCO where you can find the CEO's video, a fact sheet on the company, investor presentations, and more.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California biotechnology company focused on developing therapeutic and research products. ISCO's technology, Parthenogenesis, results in the creation of pluripotent human stem cell lines from unfertilized human eggs. ISCO scientists have created the first Parthenogenetic homozygous stem cell line (phSC-Hhom-4) that can be a source of therapeutic cells that will minimize immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. These advancements offer the potential to create the first true "Stem Cell Bank" and address ethical issues by eliminating the need to use or destroy fertilized embryos. ISCO also produces and markets specialized cells and growth media worldwide for therapeutic research through its subsidiary Lifeline Cell Technology. For more information, visit the ISCO website at: www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS:

Statements pertaining to anticipated future financial and/or operating results, future growth in research, technology, clinical development and potential joint venture and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Cornea, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman, CEO
760-940-6383
kaldrich@intlstemcell.com
or
Lifeline Cell Technology
Jeffrey Janus, CEO
janusj@lifelinecelltech.com
or
The Investor Relations Group
Laura Colontrelle
212-825-3210
lcolontrelle@investorrelationsgroup.com

International Stem Cell Corporation and Absorption Systems Announce Potential Stem Cell Alternative to Live Animal Testing for Corneal Damage

International Stem Cell Corporation (OTCBB:ISCO)(www.internationalstemcell.com), the first company to perfect a method of creating human "parthenogenetic" stem cells from unfertilized eggs, announces positive results of its collaboration with Absorption Systems to study ISCO's stem-cell-derived human corneal tissue as an alternative to live animals for drug testing. Initial results using non-animal or "in vitro" tests indicate an excellent correlation between the rates at which drugs pass through ISCO's lab-grown corneal tissue and rabbit corneal tissue. The results offer great promise for reducing the use of living animals for eye safety testing. ISCO's human corneal tissue is created from parthenogenetic stem cells in the laboratories of Lifeline Cell Technology (Walkersville, MD), ISCO's wholly-owned subsidiary. According to Dr. Chris Bode of Absorption Systems. "The rank order correlation of the eight drugs tested so far is almost perfect." The collaboration between the companies is focused on using Absorption Systems' know-how in creating assay systems to develop superior preclinical methods of testing drugs. Such methods can also reduce the use of laboratory animals currently necessary for other tests, including the very large global commercial need for a reliable and reproducible non-animal method for eye safety testing of consumer products. In the past, researchers have grown corneal cells in the laboratory, but ISCO is believed to be the only company to grow a self-assembling corneal construct from parthenogenetic stem cells that is suitable for toxicity testing and possibly suitable for corneal transplants. ISCO's corneal constructs include cell layers and structures normally found in a human cornea, as confirmed by an independent third-party laboratory. ISCO's proprietary lines of parthenogenetic stem cells remove the need for fertilized embryos and, in a therapeutic setting, may minimize the threat of immune rejection. This breakthrough was published in the peer-reviewed journal Cloning & Stem Cells (Volume 9, Number 3; September 2007:432-449 and, Volume 10, Number 1; March 2008: 11-24). "These initial experiments are very encouraging and will be followed up with more extensive testing. Absorption Systems' proficiency in performing tissue-based assays may provide a powerful and unique drug testing model for the large commercial markets in the pharmaceutical industry and the field of ophthalmology," commented Jeffrey Janus, Senior VP of ISCO and CEO of Lifeline. "In addition, this work complements ISCO's effort to use its parthenogenetic stem cells to create cell transplant therapies for diseases of the eye. We plan to further develop our corneal tissue technology with a goal of routinely growing living human corneas for ultimate use in human corneal transplants." "ISCO's corneal construct, combined with Absorption Systems' expertise in assessing drug disposition, may provide pharmaceutical and ophthalmology researchers with new insight, without the need for animal models," said Patrick M. Dentinger, President and CEO of Absorption Systems. "Absorption Systems' services yield the type of definitive data expected by the FDA, so we believe that our combined products will be of great interest to researchers studying diseases of the eye." For more news and information on International Stem Cell Corporation please visit www.IRGnews.com/coi/ISCO where you can find the CEO's video, a fact sheet on the company, investor presentations, and more. ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB): International Stem Cell Corporation is a California biotechnology company focused on developing therapeutic and research products. ISCO's technology, Parthenogenesis, results in the creation of pluripotent human stem cell lines from unfertilized human eggs. ISCO scientists have created the first Parthenogenetic homozygous stem cell line (phSC-Hhom-4) that can be a source of therapeutic cells that will minimize immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. These advancements offer the potential to create the first true "Stem Cell Bank" and address ethical issues by eliminating the need to use or destroy fertilized embryos. ISCO also produces and markets specialized cells and growth media worldwide for therapeutic research through its subsidiary Lifeline Cell Technology. For more information, visit the ISCO website at: www.internationalstemcell.com. To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0. ABOUT ABSORPTION SYSTEMS: Founded in 1996 by Patrick Dentinger and Ismael J. Hidalgo, Ph.D., Absorption Systems, LP focuses on performing assays that can predict the Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) of small molecules using a variety of in vitro, in situ, and in vivo biological models. Absorption Systems supports these assays with state-of–the-art bioanalytical capabilities and preclinical formulation services. For more information, visit: www.absorption.com FORWARD-LOOKING STATEMENTS: Statements pertaining to anticipated future financial and/or operating results, future growth in research, technology, clinical development and potential joint venture and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements. Key Words: Stem Cells, Biotechnology, Parthenogenesis Photos/Multimedia Gallery Available: http://www.businesswire.com/cgi-bin/mmg.cgi?eid=6064890&lang=en International Stem Cell Corporation Kenneth C. Aldrich, Chairman, CEO kaldrich@intlstemcell.com William B. Adams, Co-Founder, 760-940-6383 wadams@intlstemcell.com Jeffrey Janus, 760-940-6383 CEO, Lifeline Cell Technology Senior VP, International Stem Cell Corporation janusj@lifelinecelltech.com or The Investor Relations Group Media Relations: Laura Colontrelle, 212-825-3210 lcolontrelle@investorrelationsgroup.com or Schwartz Communications Andrea tenBroek or Wendy Mejia, 781-684-0770 absorptionsystems@schwartz-pr.com

International Stem Cell Corporation Issues Letter to Shareholders

Letter Describes Capital Funding, Strengthening of Senior Management Team, Agreement with Cytograft Tissue Engineering, Positive Results from Animal Trials, and Other Developments

International Stem Cell Corporation (OTCBB:ISCO), the first company to perfect a method of creating human stem cells from unfertilized eggs, has issued a letter to its shareholders. To view the shareholder letter in its entirety, please follow the link to the company's website: http://www.internationalstemcell.com/shareholderletter.htm.

In the letter, International Stem Cell CEO and Chairman, Kenneth Aldrich updates shareholders on the company's continued efforts to increase shareholder value related to its key initiatives and developments, which include:

* The Company continues to lead in the development of human parthenogenetic stem cell ("hpSC") research. ISCO has made major strides in deriving cells that may be useful in the treatment of liver disease and in the creation of human corneal tissue both as a potential therapeutic product for corneal disease and as an alternative to animal testing to assess the safety of drugs and consumer products.

* $5 million investment commitment with a biotechnology-focused fund announced in July; funding expected to be in tranches, with first $1.5 million expected in September. Additional $1 million tranche funded on schedule under previously announced preferred stock offering, and over $500,000 in private common stock sales funded during first 6 months of 2009

* Senior management team strengthened to provide greater capacity and flexibility as company expands its therapeutic and commercial activities

* Positive early results reported in May from animal trials designed to improve photorefractive keratectomy (PRK), a form of corrective laser eye surgery that offers an improved alternative to LASIK

* March 2009 agreement with Cytograft Tissue Engineering to design custom cell culture medium to cultivate living human vascular grafts

"Viewed from a scientific, political, managerial, and financial perspective, the past six months have been a vibrant and compelling time in our corporate history," says Mr. Aldrich. "The company remains committed to its vision of creating the means to manufacture, bank, and provide cells for patients that need them, on demand, at low cost, without the risk of immune rejection. We look forward to our shareholders reviewing this update, thank them for their steadfastness and support, and look forward to our shared work in the months and years ahead."

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB)

International Stem Cell Corporation is a California biotechnology company focused on developing therapeutic and research products. ISCO's technology, Parthenogenesis, results in the creation of pluripotent human stem cell lines from unfertilized human eggs. ISCO scientists have created the first Parthenogenetic homozygous stem cell line (phSC-Hhom-4) that can be a source of therapeutic cells that will minimize immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. These advancements offer the potential to create the first true "Stem Cell Bank" and address ethical issues by eliminating the need to use or destroy fertilized embryos. ISCO also produces and markets specialized cells and growth media worldwide for therapeutic research through its subsidiary Lifeline Cell Technology. For more information, visit the ISCO website at: www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

For more news and information on International Stem Cell Corporation please visit www.IRGnews.com/coi/ISCO where you can find the CEO's video, a fact sheet on the company, investor presentations, and more.

FORWARD-LOOKING STATEMENTS:

Statements pertaining to expected future financial and/or operating results, anticipated funding, future research, technology and clinical development plans and potential opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the completion of funding commitments, the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital,and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman, CEO
kaldrich@intlstemcell.com
760-940-6383
or
The Investor Relations Group
212-825-3210
Investor Relations:
Adam S. Holdsworth
aholdsworth@investorrelationsgroup.com
or
Media Relations:
Laura Colontrelle
lcolontrelle@investorrelationsgroup.com

International Stem Cell Corporation Adds Strength Through Expansion of its Management Structure

International Stem Cell Corporation (OTCBB:ISCO) has expanded its senior management team to include greater capacity and flexibility as it expands its therapeutic and commercial activities for the remainder of 2009 and beyond.

Professor Andrei Semetchkine, Ph.D., who is already a director and officer of the Company, will assume the duties of Executive Vice President of ISCO, with broad responsibility for the strategy, financial, and business affairs of the company. Dr. Semetchkine, a resident of Southern California, has been for many years a member of the prestigious Russian Academy of Sciences, the highest scientific body in Russia, and has been a founder or senior executive of many international businesses. "Dr. Semetchkine brings a depth of management skills, knowledge of opportunities in international science and a world experience that will be extremely valuable to our Company in the days to come," said Kenneth Aldrich, Chairman, President and CEO of ISCO.

Jeffrey Janus, will continue to be CEO and President of Lifeline Cell Technology, the revenue generating subsidiary of ISCO, and will also serve as Senior Vice President of Operations for the parent Company, ISCO. "As ISCO and Lifeline have grown, the demands have increased," said Mr. Janus. "The addition of Dr. Semetchkine to the senior management of ISCO will add tremendous strength to our strategic planning and management capabilities as we move forward towards therapeutic use of our parthenogenetic stem cells and to help us manage the expansion of both ISCO and Lifeline more effectively."

In a final change, Ray Wood, who had been the controller of the company, has been promoted to Vice President, Finance and Principal Financial Officer. Mr. Wood has extensive public and private company experience that is expected to enhance ISCO's financial and accounting strength.

Mr. Wood's appointment will also permit William Adams, a founder of the Company to step down from his role as CFO as of June 30, 2009. He will now work full time on developing new capital sources and collaborative opportunities for the Company. Mr. Adams is responsible for much of the company's financing to date, and this change will allow him to focus more effectively on future needs of the Company, particularly in establishing new industry and research collaborations. Mr. Adams has also elected to resign from the Board of Directors, effective June 30, 2009, and will assist the Company in seeking an outside Board member with relevant industry and regulatory affairs experience to fill the vacant seat. "I am by no means leaving the Company," said Mr. Adams. "I am just refocusing my efforts where I believe I can be of the greatest help to the company's future."

For more news and information on International Stem Cell Corporation please visit www.IRGnews.com/coi/ISCO where you can find the CEO's video, a fact sheet on the company, investor presentations, and more.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California biotechnology company focused on developing therapeutic and research products. ISCO's technology, Parthenogenesis, results in the creation of pluripotent human stem cell lines from unfertilized human eggs. ISCO scientists have created the first Parthenogenetic homozygous stem cell line (phSC-Hhom-4) that can be a source of therapeutic cells that will minimize immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. These advancements offer the potential to create the first true "Stem Cell Bank" and address ethical issues by eliminating the need to use or destroy fertilized embryos. ISCO also produces and markets specialized cells and growth media worldwide for therapeutic research through its subsidiary Lifeline Cell Technology. For more information, visit the ISCO website at: www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS:

Statements pertaining to anticipated future financial and/or operating results, future growth in research, technology, clinical development and potential joint venture and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman, CEO
760-940-6383
kaldrich@intlstemcell.com
or
The Investor Relations Group
212-825-3210
Investor Relations:
Adam S. Holdsworth
aholdsworth@investorrelationsgroup.com
or
Media Relations:
Laura Colontrelle
lcolontrelle@investorrelationsgroup.com

International Stem Cell Corporation Secures $5 Million Financing Commitment

International Stem Cell Corporation (OTCBB:ISCO), has entered into a definitive agreement for a $5 million investment commitment (the "Investment") with a biotechnology-focused fund (the "Investor") that has offices in New York and California. The Investment will be used to fund operations and working capital needs of the company and expand its scientific research. Proceeds of the investment provide a valuable addition to the company's capital structure. Together with the private capital already committed to the company and its internally generated revenue, these funds are expected to provide the capital needed by ISCO for the balance of 2009 and a significant amount of the capital expected to be needed in 2010.

The Company may draw down funds from the Investor as it finds a need, but is not obligated to do so. Funds will be drawn down through the issuance of Series E Preferred Stock (the "Preferred Stock"). The Preferred Stock will not be convertible into common stock and may be redeemed by the Company after one year. Each issue of Preferred Stock will be accompanied by the issuance of five-year warrants to purchase common stock at 100% of the closing price of the company's common stock on the day prior to the date the company gives notice of its election to draw funds. The total exercise value of warrants issued will equal 135% of the drawdown amount. Dividends on the Preferred Stock are payable in additional shares of non-convertible Preferred Stock at the rate of 10% per annum. A commitment fee of $250,000, payable in shares of common stock, was made to the Investor.

"The flexibility of this financing will add greatly to our financial strength," commented Kenneth Aldrich, CEO and Chairman of ISCO. "We are pleased that we have secured a financing source that will be available to us at the time of our own choosing over the next year."

For more news and information on International Stem Cell Corporation please visit www.IRGnews.com/coi/ISCO where you can find the CEO's video, a fact sheet on the company, investor presentations, and more.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California biotechnology company focused on developing therapeutic and research products. ISCO's technology, Parthenogenesis, results in the creation of pluripotent human stem cell lines from unfertilized human eggs. ISCO scientists have created the first Parthenogenetic homozygous stem cell line (phSC-Hhom-4) that can be a source of therapeutic cells that will minimize immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. These advancements offer the potential to create the first true "Stem Cell Bank" and address ethical issues by eliminating the need to use or destroy fertilized embryos. ISCO also produces and markets specialized cells and growth media worldwide for therapeutic research through its subsidiary Lifeline Cell Technology. For more information, visit the ISCO website at: www.internationalstemcell.com.

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FORWARD-LOOKING STATEMENTS:

Statements pertaining to anticipated future financial and/or operating results, future growth in research, technology, clinical development and potential joint venture and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman, CEO
760-940-6383
kaldrich@intlstemcell.com
or
The Investor Relations Group
212-825-3210
Investor Relations:
Adam S. Holdsworth
aholdsworth@investorrelationsgroup.com
or
Media Relations:
Laura Colontrelle
lcolontrelle@investorrelationsgroup.com